Development and Validation of a Computational Model for Androgen Receptor Activity

Author:

Kleinstreuer Nicole C.1ORCID,Ceger Patricia2,Watt Eric D.3ORCID,Martin Matthew3,Houck Keith3,Browne Patience4,Thomas Russell S.3,Casey Warren M.1,Dix David J.5,Allen David2,Sakamuru Srilatha6,Xia Menghang6,Huang Ruili6,Judson Richard3

Affiliation:

1. NIH/NIEHS/DNTP/The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, Research Triangle Park, North Carolina 27713, United States

2. Integrated Laboratory Systems, Inc., Research Triangle Park, North Carolina 27560, United States

3. EPA/ORD/National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711, United States

4. OECD Environment Directorate, Environment Health and Safety Division, Paris 75775, France

5. EPA/OCSPP/Office of Science Coordination and Policy, Washington, DC, 20460, United States

6. NIH/National Center for Advancing Translational Sciences, Bethesda, Maryland 20892, United States

Funder

National Institute of Environmental Health Sciences

U.S. Environmental Protection Agency

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference44 articles.

1. U.S. EPA, EndocrineDisruptor Screening Program (EDSP) Overview.Online: https://www.epa.gov/endocrine-disruption/endocrine-disruptor-screening-program-edsp-overview(accessed November 10, 2015), 2012.

2. U.S. EPA, EndocrineDisruptor Screening Program Universeof Chemicals and General Validation Principles. Online: http://www.epa.gov/endo/pubs/edsp_chemical_universe_and_general_validations_white_paper_11_11.pdf(accessed November 10, 2015), 2012.

3. U.S. EPA, The Incorporation of In Silico Models and In VitroHigh Throughput Assays in the Endocrine Disruptor Screening Program(EDSP) for Prioritization and Screening. Summary Overview. A Partof the EDSP Comprehensive Management Plan Online: http://epa.gov/endo/pubs/edsp21_work_plan_summary_overview_final.pdf(accessed November 10, 2015), 2011.

4. Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

5. Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

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