Diminished Phosphorylation of CREB Is a Key Event in the Dysregulation of Gluconeogenesis and Glycogenolysis in PCB126 Hepatotoxicity

Author:

Gadupudi Gopi S.1,Klingelhutz Aloysius J.2,Robertson Larry W.1

Affiliation:

1. Interdisciplinary Graduate Program in Human Toxicology and Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242, United States

2. Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, United States

Funder

National Institute of Environmental Health Sciences

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference43 articles.

1. Polychlorinated Biphenyls, Lead, and Mercury Are Associated with Liver Disease in American Adults: NHANES 2003–2004

2. Polychlorinated Biphenyl (PCB) Exposure and Diabetes: Results from the Anniston Community Health Survey

3. Association of a polychlorinated dibenzo-p-dioxin, a polychlorinated biphenyl, and DDT with diabetes in the 1999–2002 National Health and Nutrition Examination Survey

4. NTP (2006) NTP Toxicology and Carcinogenesis Studies of 3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies), inNational Toxicology Program Technical Report Series,National Toxicology Program, Public Health Service, U.S. Department of Health and Human Services,Research Triangle Park, North Carolina, pp4–246.

5. Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor

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