Identification of a Fused-Ring 2′-Deoxyadenosine Adduct Formed in Human Cells Incubated with 1-Chloro-3-buten-2-one, a Potential Reactive Metabolite of 1,3-Butadiene

Author:

Zeng Fang-Mao1,Liu Ling-Yan1,Zheng Jin1,Kong Cong2,An Jing1,Yu Ying-Xin1,Zhang Xin-Yu1,Elfarra Adnan A.3

Affiliation:

1. Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China

2. East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China

3. Department of Comparative Biosciences and the Molecular and Environmental Toxicology Center, University of Wisconsin—Madison, Madison, Wisconsin 53706, United States

Funder

Foundation for the National Institutes of Health

The Shanghai Municipal Education Commission

The Shanghai Leading Academic Discipline Project

The National Nature Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference29 articles.

1. Koppikar, A. M., Wu, C., Leavens, T., Valcovic, L., Kimmel, C., Faust, R., and Jinot, J. (2002) Health Assessment of 1,3-Butadiene, EPA/600/P-98/001F,U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment-Washington Office, U.S. Government Printing Office,Washington, DC,http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=54499(accessed Mar 19, 2016).

2. 1,3-Butadiene oxidation by human myeloperoxidase. Role of chloride ion in catalysis of divergent pathways.

3. Alcohol Dehydrogenase- and Rat Liver Cytosol-Dependent Bioactivation of 1-Chloro-2-hydroxy-3-butene to 1-Chloro-3-buten-2-one, a Bifunctional Alkylating Agent

4. Ranking Cancer Risks of Organic Hazardous Air Pollutants in the United States

5. Characterization of the Chronic Risk and Hazard of Hazardous Air Pollutants in the United States Using Ambient Monitoring Data

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