Cytochrome P450 Enzyme-Mediated Bioactivation as an Underlying Mechanism of Columbin-Induced Hepatotoxicity-Reference-Cited by-同舟云学术

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Cytochrome P450 Enzyme-Mediated Bioactivation as an Underlying Mechanism of Columbin-Induced Hepatotoxicity

Published:2020-03-12 Issue:4 Volume:33 Page:940-947
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Pei Jiaping¹²,Xiao Wen³,Zhu Danyan¹,Ji Xiaowei¹,Shi Liping¹,Deng Xiaozhao¹²^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanjing Medical University, Nanjing 210029, China

2. Huadong Research Institute for Medicine and Biotechnics, No. 293, Zhongshan East Road, Nanjing 210002, China

3. School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China

Funder

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.9b00486

Reference19 articles.

1. Main antimicrobial components ofTinospora capillipes, and their mode of action againstStaphylococcus aureus

2. Characterization of isoquinoline alkaloids, diterpenoids and steroids in the Chinese herb Jin-Guo-Lan (Tinospora sagittata andTinospora capillipes) by high-performance liquid chromatography/electrospray ionization with multistage mass spectrometry

3. In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation

4. Columbin inhibits cholesterol uptake in bloodstream forms ofTrypanosoma brucei-A possible trypanocidal mechanism

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2. Clerodane diterpenoids with in-vitro anti-neuroinflammatory activity from the tuberous root of Tinospora sagittata (Menispermaceae);Phytochemistry;2024-02

3. Exploring the Mechanism of Hepatotoxicity Induced by Dictamnus dasycarpus Based on Network Pharmacology, Molecular Docking and Experimental Pharmacology;Molecules;2023-06-28

4. DNA damage and up-regulation of PARP-1 induced by columbin in vitro and in vivo;Toxicology Letters;2023-04

5. Immunochemical and LC–MS/MS Detection of Protein Adduction Resulting from Metabolic Activation of Columbin In Vitro and In Vivo;Chemical Research in Toxicology;2023-03-28

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