Structure–Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates-Reference-Cited by-同舟云学术

Structure–Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates

Published:2019-12-04 Issue:12 Volume:32 Page:2488-2498
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Kowalski John P.¹^ORCID,McDonald Matthew G.¹,Whittington Dale¹,Guttman Miklos¹^ORCID,Scian Michele¹,Girhard Marco²,Hanenberg Helmut³,Wiek Constanze⁴,Rettie Allan E.¹

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington 98105, United States

2. Institute of Biochemistry, Heinrich-Heine University, 40225 Düsseldorf, Germany

3. Department of Pediatrics III, University Children’s Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany

4. Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, 40225 Düsseldorf, Germany

Funder

University of Washington

Heinrich-Heine-Universit?t D?sseldorf

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.9b00330

Reference33 articles.

1. CYP4 Enzymes As Potential Drug Targets: Focus on Enzyme Multiplicity, Inducers and Inhibitors, and Therapeutic Modulation of 20- Hydroxyeicosatetraenoic Acid (20-HETE) Synthase and Fatty Acid ω- Hydroxylase Activities

2. CYP4B1: An Enigmatic P450 at the Interface between Xenobiotic and Endobiotic Metabolism

3. Identification of a Meander Region Proline Residue Critical for Heme Binding to Cytochrome P450: Implications for the Catalytic Function of Human CYP4B1

4. Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol

5. Bioactivation of 4-Ipomeanol by CYP4B1: Adduct Characterization and Evidence for an Enedial Intermediate

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