Chemical and Enzymatic Transformations of Nimesulide to GSH Conjugates through Reductive and Oxidative Mechanisms
Author:
Affiliation:
1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, P.R. China
Funder
National Natural Science Foundation of China
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.5b00290
Reference42 articles.
1. Nimesulide: an NSAID that preferentially inhibits COX-2, and has various unique pharmacological activities
2. Nimesulide – a multifactorial approach to inflammation and pain: scientific and clinical consensus
3. Fatal hepatotoxicity secondary to nimesulide
4. Acute cholestatic hepatitis induced by nimesulide
5. COX-2 inhibitor (nimesulide) induced acute liver failure
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