The In Vitro Pharmacological Profile of Drugs as a Proxy Indicator of Potential In Vivo Organ Toxicities-Reference-Cited by-同舟云学术

The In Vitro Pharmacological Profile of Drugs as a Proxy Indicator of Potential In Vivo Organ Toxicities

Published:2016-03-16 Issue:4 Volume:29 Page:637-648
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Remez Nikita¹²,Garcia-Serna Ricard²,Vidal David²,Mestres Jordi¹²

Affiliation:

1. Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical Research Institute and University Pompeu Fabra, Parc de Recerca Biomèdica, Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain

2. Chemotargets SL, Parc Científic de Barcelona, Baldiri Reixac 4 (TI-05A7), 08028 Barcelona, Catalonia, Spain

Funder

European Commission

Ministerio de Economía y Competitividad

Agència de Gestió d’Ajuts Universitaris i de Recerca

European Federation of Pharmaceutical Industries and Associations

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.5b00470

Reference70 articles.

1. Target organ toxicities in studies conducted to support first time in man dosing: An analysis across species and therapy areas

2. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

3. The EU White Paper: Strategy for a Future Chemicals Policy (an Idea that Must Have Seemed Good at the Time!)

4. The adult human brain in preclinical drug development

5. Adult human brain cell culture for neuroscience research

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