Chlorine Functionalization of a Model Phenolic C8-Guanine Adduct Increases Conformational Rigidity and Blocks Extension by a Y-Family DNA Polymerase
Author:
Affiliation:
1. Departments of Chemistry and Toxicology, University of Guelph, Guelph, ON, Canada N1G 2W1
2. Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
Funder
Canada Foundation for Innovation
Canada Research Chairs
Natural Sciences and Engineering Research Council of Canada
Ontario Research Fund
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.5b00143
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3. Polychlorinated Biphenyls and Non-Hodgkin Lymphoma
4. Toxicity of Chlorinated Organic Compounds: Effects of the Introduction of Chlorine in Organic Molecules
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2. Adduct Fluorescence as a Tool to Decipher Sequence Impact on Frameshift Mutations Mediated by a C-Linked C8-Biphenyl-Guanine Lesion;Chemical Research in Toxicology;2019-02-20
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4. Conformational Preference and Fluorescence Response of a C-Linked C8-Biphenyl-Guanine Lesion in the NarI Mutational Hotspot: Evidence for Enhanced Syn Adduct Formation;Chemical Research in Toxicology;2017-12-14
5. Molecular Modeling of the Major DNA Adduct Formed from Food Mutagen Ochratoxin A in NarI Two-Base Deletion Duplexes: Impact of Sequence Context and Adduct Ionization on Conformational Preference and Mutagenicity;Chemical Research in Toxicology;2017-08-08
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