9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats

Author:

Chen Meixia1,Li Liang1,Zhong Dafang1,Shen Shuijie2,Zheng Jiang23,Chen Xiaoyan1

Affiliation:

1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, China

2. Center for Developmental Therapeutics, Seattle Children’s Research Institute, Division of Gastroenterology and Hepatology, Department of Pediatrics, University of Washington, Seattle, Washington 98195, United States

3. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference34 articles.

1. WHO (1988) Environmental Health Critaria 80 Pyrrolizidine Alkaloids.http://www.inchem.org/documents/ehc/ehc/ehc080.htm#SectionNumber:3.1.

2. Toxicity of Pyrrolizidine Alkaloids

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