ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics

Author:

Oliveira Rodrigo Juliano12,da Silveira Ingridhy Ostaciana Maia Freitas34,das Neves Silvia C.12,Mitsuyasu Barbara45,Martins Allana C.4,Berno Claudia1,Mohammad Jiyan4,Raj Halie4,de Araujo Flavio H. S.1,Hortelan Cristiane Regina6,Machado Luana78,da Silva Júnior Eufrânio N.7,Vilela Marcelo L. B.9,Nascimento Valter Aragão2,Beatriz Adilson3ORCID,da Silva Gomes Roberto4ORCID

Affiliation:

1. Stem Cell, Cell Therapy and Toxicological Genetics Research Centre (CeTroGen), Medical School, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul79080-190, Brazil

2. Graduate Program in Health and Development in the Midwest Region, Medical School, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul79070-900, Brazil

3. Institute of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul79070-900, Brazil

4. Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota58102, United States

5. Department of Chemical and Biological Sciences, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP18618-689, Brazil

6. Instituto Federal de Mato Grosso do Sul, Dourados, MSCEP 79833-520, Brazil

7. Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, MGCEP 31270-901, Brazil

8. Department of Chemistry, Fluminense Federal University, Niteroi, RJ24020-141, Brazil

9. Medical School, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul79070-900, Brazil

Funder

Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico

North Dakota State University

Funda??o de Amparo ? Pesquisa e Inova??o do Estado de Santa Catarina

National Institute of General Medical Sciences

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior

North Dakota Established Program to Stimulate Competitive Research

Instituto Nacional de Ci?ncia e Tecnologia - Cat?lise

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

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