Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury-Reference-Cited by-同舟云学术

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Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury

Published:2022-10-26 Issue:11 Volume:35 Page:2133-2144
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Rana Payal¹^ORCID,Khan Sanaa¹,Arat Seda¹^ORCID,Potter David²,Khan Nasir¹

Affiliation:

1. Drug Safety Research and Development, Pfizer, Groton, Connecticut 06340, United States

2. Early Clinical Development Biostatistics, Pfizer, Inc., Cambridge, Massachusetts 02139, United States

Funder

Pfizer

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.2c00243

Reference41 articles.

1. WITHDRAWN—a resource for withdrawn and discontinued drugs

2. An investigation into drug products withdrawn from the EU market between 2002 and 2011 for safety reasons and the evidence used to support the decision-making

3. Today’s Challenges to De-Risk and Predict Drug Safety in Human “Mind-the-Gap”

4. Safety data and withdrawal of hepatotoxic drugs

5. Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

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