Quantum-Mechanical Approach to Predicting the Carcinogenic Potency of N-Nitroso Impurities in Pharmaceuticals
Author:
Affiliation:
1. Designing Out Toxicity (DOT) Consulting LLC, 2121 Eisenhower Avenue, Alexandria, Virginia22314, United States
2. The George Washington University, 800 22nd Street NW, Washington, D.C.20052, United States
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.2c00380
Reference82 articles.
1. The EU Response to the Presence of Nitrosamine Impurities in Medicines
2. The Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals
3. European Medicines Agency. Nitrosamine Impurities Report 2020, https://www.ema.europa.eu/en/human-regulatory/post-authorisation/referral-procedures/nitrosamine-impurities (accessed July 31, 2022).
4. European Medicines Agency. Temporary Interim Limits for NMBA, DIPNA, EIPNA, Impurities in Sartan Blood Pressure Medicines 2019. EMA/351053/2019 rev 1, 2019.
5. Developing structure-activity relationships for N-nitrosamine activity
Cited by 14 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Molecular similarity in chemical informatics and predictive toxicity modeling: from quantitative read-across (q-RA) to quantitative read-across structure–activity relationship (q-RASAR) with the application of machine learning;Critical Reviews in Toxicology;2024-09-03
2. N-nitrosamine impurity risk assessment in pharmaceuticals: Utilizing In vivo mutation relative potency comparison to establish an acceptable intake for NTTP;Regulatory Toxicology and Pharmacology;2024-09
3. Estimation of acceptable daily intake values based on modeling and in vivo mutagenicity of NDSRIs of fluoxetine, duloxetine and atomoxetine;Regulatory Toxicology and Pharmacology;2024-09
4. Analytical Methodologies to Detect N-Nitrosamine Impurities in Active Pharmaceutical Ingredients, Drug Products and Other Matrices;Chemical Research in Toxicology;2024-08-19
5. A Kinetic Model for Assessing Potential Nitrosamine Carcinogenicity;Chemical Research in Toxicology;2024-07-29
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3