Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O6-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O6-Alkylguanine Adductome-Reference-Cited by-同舟云学术

Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O⁶-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O⁶-Alkylguanine Adductome

Published:2023-11-20 Issue:12 Volume:36 Page:1921-1929
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Abdelhady Rasha¹,Senthong Pattama¹,Eyers Claire E.²,Reamtong Onrapak²,Cowley Elizabeth¹,Cannizzaro Luca²,Stimpson Joanna²,Cain Kathleen²,Wilkinson Oliver J.³,Williams Nicholas H.³^ORCID,Barran Perdita E.²^ORCID,Margison Geoffrey P.¹,Williams David M.³^ORCID,Povey Andrew C.¹^ORCID

Affiliation:

1. Epidemiology and Public Health Group, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, U.K.

2. Department of Chemistry and Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, U.K.

3. Centre for Chemical Biology, Department of Chemistry, Sheffield Institute for Nucleic Acids, University of Sheffield, Sheffield S3 7HF, U.K.

Funder

Ministry of Higher Education

Research Councils UK

Cancer Research UK

Thai Government

UoM-Weizmann Institute of Science

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine