Latent Variables Capture Pathway-Level Points of Departure in High-Throughput Toxicogenomic Data

Author:

Basili Danilo12ORCID,Reynolds Joe2,Houghton Jade2,Malcomber Sophie2,Chambers Bryant3,Liddell Mark2,Muller Iris2,White Andrew2,Shah Imran3ORCID,Everett Logan J.3,Middleton Alistair2,Bender Andreas1ORCID

Affiliation:

1. Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.

2. Unilever, Safety and Environmental Assurance Centre (SEAC), Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, U.K.

3. Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States

Funder

Unilever

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference65 articles.

1. Toxicity testing is evolving!

2. Zuang, V.; Dura, A.; Asturiol Bofill, D.; Batista Leite, S.; Berggren, E.; Bopp, S.; Carpi, D.; Casati, S.; Coecke, S.; Corvi, R.; Deceuninck, P.; Franco, A.; Gribaldo, L.; Halder, M. E.; Holloway, M.; Kienzler, A.; Langezaal, I.; Madia, F.; Milcamps, A.; Munn, S.; Paini, A.; Piergiovanni, M.; Pistollato, F.; Price, A.; Prieto Peraita, M. D. P.; Viegas Barroso, J. F.; Wittwehr, C.; Worth, A.; Whelan, M. Non-Animal Methods in Science and Regulation, 2020.

3. Assuring safety without animal testing: Unilever’s ongoing research programme to deliver novel ways to assure consumer safety

4. Non-Animal Approaches for Consumer Safety Risk Assessments: Unilever's Scientific Research Programme

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