Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in Vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis

Author:

Melnikov Fjodor1ORCID,Botta Dianne2,White Collin C.2,Schmuck Stefanie C.2,Winfough Matthew3,Schaupp Christopher M.2,Gallagher Evan P.2,Brooks Bryan W.4ORCID,Williams Edward Spencer4,Coish Philip1,Anastas Paul T.15ORCID,Voutchkova-Kostal Adelina3,Kostal Jakub3,Kavanagh Terrance J.2ORCID

Affiliation:

1. Yale School of Forestry and Environmental Sciences, Yale University, New Haven, Connecticut 06520, United States

2. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, United States

3. Department of Chemistry, George Washington University, Washington, D.C. 20052, United States

4. Department of Environmental Science, Baylor University, Waco, Texas 76798, United States

5. School of Public Health, Yale University, New Haven, Connecticut 06520, United States

Funder

National Institute of Environmental Health Sciences

Division of Chemistry

U.S. Environmental Protection Agency

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference132 articles.

1. Toward a Comprehensive Molecular Design Framework for Reduced Hazard

2. DeVito, S. C. (1996) In Designing Safer Chemicals, ACS Symposium Series, American Chemical Society, Washington, DC, pp 2–16.

3. The Green ChemisTREE: 20 years after taking root with the 12 principles

4. The Molecular Design Research Network

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