Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1-Reference-Cited by-同舟云学术

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Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1

Published:2019-01-31 Issue:3 Volume:32 Page:484-492
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Albertolle Matthew E.¹,Song Hyun D.²,Wilkey Clayton J.¹,Segrest Jere P.²,Guengerich F. Peter¹^ORCID

Affiliation:

1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States

2. Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6300, United States

Funder

National Heart, Lung, and Blood Institute

American Heart Association

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.8b00353

Reference55 articles.

1. CYP4B1: An Enigmatic P450 at the Interface between Xenobiotic and Endobiotic Metabolism

2. Positional Specificity of Rabbit CYP4B1 for ω-Hydroxylation1of Short-Medium Chain Fatty Acids and Hydrocarbons

3. Expression patterns of mouse and human CYP orthologs (families 1–4) during development and in different adult tissues

4. Ligand characterization of CYP4B1 isoforms modified for high-level expression inEscherichia coliand HepG2 cells

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1. Analysis of critical residues for peroxygenation and improved peroxygenase activity via in situ H2O2 generation in CYP105D18;Frontiers in Microbiology;2023-12-11

2. Key regulators in the architecture of substrate access/egress channels in mammalian cytochromes P450 governing flexibility in substrate oxyfunctionalization;Journal of Inorganic Biochemistry;2023-04

3. Characterization of high-H2O2-tolerant bacterial cytochrome P450 CYP105D18: insights into papaverine N-oxidation;IUCrJ;2021-06-29

4. Correction to Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1;Chemical Research in Toxicology;2021-01-21

5. Tight binding of cytochrome b5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis;Journal of Biological Chemistry;2021-01

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