Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6

Author:

Bester Stephanie M.1,Guelta Mark A.2,Cheung Jonah3ORCID,Winemiller Mark D.2ORCID,Bae Su Y.2,Myslinski James2,Pegan Scott D.12ORCID,Height Jude J.2

Affiliation:

1. Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, United States

2. Edgewood Chemical Biological Center, United States Army, Aberdeen Proving Ground, Aberdeen, Maryland 21010, United States

3. New York Structural Biology Center, New York, New York 10027, United States

Funder

Defense Threat Reduction Agency

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference59 articles.

1. Paddock, R., Sang-Hun, C., and Wade, N. (2017) In Kim Jong-nam’s Death, North Korea Lets Loose a Weapon of Mass Destruction, New York Times, New York Times Company, New York, https://www.nytimes.com/2017/02/24/world/asia/north-korea-kim-jong-nam-vx-nerve-agent.html (accessed Mar 7, 2017).

2. Kingsley, P., and Barnard, A. (2017) Banned Nerve Agent Sarin Used in Syria Chemical Attack, Turkey Says, New York Times, New York Times Company, New York, https://www.nytimes.com/2017/04/06/world/middleeast/chemical-attack-syria.html (accessed Apr 10, 2017).

3. Barry, E., and Yeginsu, C. (2018) The Nerve Agent Too Deadly to Use, Until Someone Did, New York Times, New York Times Company, New York, https://www.nytimes.com/2018/03/13/world/europe/uk-russia-spy-poisoning.html (accessed Mar 23, 2018).

4. Patterns and problems of deliberate self-poisoning in the developing world

5. Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

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