Clarification of the Mechanism of Acylation Reaction and Origin of Substrate Specificity of the Serine-Carboxyl Peptidase Sedolisin through QM/MM Free Energy Simulations-Reference-Cited by-同舟云学术

Clarification of the Mechanism of Acylation Reaction and Origin of Substrate Specificity of the Serine-Carboxyl Peptidase Sedolisin through QM/MM Free Energy Simulations

Published:2011-02-18 Issue:10 Volume:115 Page:2470-2476
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Xu Qin¹,Yao Jianzhuang¹,Wlodawer Alexander²,Guo Hong¹

Affiliation:

1. Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 3799, United States

2. Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702, United States

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp1122294

Reference43 articles.

1. Purification and properties of a pepstatin-insensitive carboxyl proteinase from a Gram-negative bacterium

2. Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases.

3. Sedolisins, a New Class of Secreted Proteases from Aspergillus fumigatus with Endoprotease or Tripeptidyl-Peptidase Activity at Acidic pHs

4. Evolution of prokaryotic subtilases: Genome-wide analysis reveals novel subfamilies with different catalytic residues

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Serine-Carboxyl Peptidases, Sedolisins: From Discovery to Evolution;Biochemistry;2022-07-21

2. Water in Enzyme Catalysis as a Promoter and Chemical Reagent;Biological Water;2021

3. QM/MM free energy Simulations of an efficient Gluten Hydrolase (Kuma030) Implicate for a Reactant-State Based Protein-Design Strategy for General Acid/Base Catalysis;Scientific Reports;2018-05-04

4. Improvement of the self-consistent-charge density-functional-tight-binding theory by a modified Mulliken charge;Theoretical Chemistry Accounts;2017-10

5. QM/MM Investigation of Substrate and Product Specificities of Suv4-20h2: How Does This Enzyme Generate Dimethylated H4K20 from Monomethylated Substrate?;Journal of Chemical Theory and Computation;2017-05-22