Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists-Reference-Cited by-同舟云学术

Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists

Published:2009-11-10 Issue:24 Volume:52 Page:7962-7965
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Evans Karen A.¹,Budzik Brian W.¹,Ross Sean A.²,Wisnoski David D.¹,Jin Jian¹,Rivero Ralph A.¹,Vimal Mythily³,Szewczyk George R.²,Jayawickreme Channa⁴,Moncol David L.⁴,Rimele Thomas J.⁴,Armour Susan L.⁴,Weaver Susan P.⁴,Griffin Robert J.²,Tadepalli Sarva M.²,Jeune Michael R.²,Shearer Todd W.²,Chen Zibin B.²,Chen Lihong²,Anderson Donald L.²,Becherer J. David²,De Los Frailes Maite⁵,Colilla Francisco Javier⁵

Affiliation:

1. Discovery Medicinal Chemistry, Discovery Research, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, P.O. Box 5089, Collegeville, Pennsylvania 19426-0989

2. Metabolic Diseases Center of Excellence for Drug Discovery

3. Discovery Medicinal Chemistry, Discovery Research, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CMI9 5AD, U.K.

4. Discovery Research

5. Department of Screening and Compound Profiling, Discovery Research, GlaxoSmithKline Pharmaceuticals, C/Santiago Grisolia 4, 28760 Tres Cantos, Madrid, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901434t

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4. Targeting bile-acid signalling for metabolic diseases

5. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1

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