Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors-Reference-Cited by-同舟云学术

Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors

Published:2004-04-13 Issue:10 Volume:47 Page:2587-2598
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Magnin David R.¹,Robl Jeffrey A.¹,Sulsky Richard B.¹,Augeri David J.¹,Huang Yanting¹,Simpkins Ligaya M.¹,Taunk Prakash C.¹,Betebenner David A.¹,Robertson James G.¹,Abboa-Offei Benoni E.¹,Wang Aiying¹,Cap Michael¹,Xin Li¹,Tao Li¹,Sitkoff Doree F.¹,Malley Mary F.¹,Gougoutas Jack Z.¹,Khanna Ashish¹,Huang Qi¹,Han Song-Ping¹,Parker Rex A.¹,Hamann Lawrence G.¹

Affiliation:

1. Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design, Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049924d

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1. Current Therapies and Emerging Targets for the Treatment of Diabetes

2. Prevalence of Diabetes and Impaired Glucose Tolerance and Plasma Glucose Levels in U.S. Population Aged 20–74 Yr

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