Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists-Reference-Cited by-同舟云学术

Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Published:2009-04-10 Issue:9 Volume:52 Page:3084-3092
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gilligan Paul J.¹,Clarke Todd¹,He Liqi¹,Lelas Snjezana¹,Li Yu-Wen¹,Heman Karen¹,Fitzgerald Lawrence¹,Miller Keith¹,Zhang Ge¹,Marshall Anne¹,Krause Carol¹,McElroy John F.¹,Ward Kathyrn¹,Zeller Kim¹,Wong Harvey¹,Bai Steven¹,Saye Joanne¹,Grossman Scott¹,Zaczek Robert¹,Arneric Stephen P.¹,Hartig Paul¹,Robertson David¹,Trainor George¹

Affiliation:

1. Bristol-Myers Squibb Co., 311 Pennington-Rocky Hill Road, Hopewell, New Jersey 08540, Bristol-Myers Squibb Co., 5 Research Parkway, Wallingford, Connecticut 06492, and Bristol-Myers Squibb Co., Route 206 and Province Line Road, Princeton, New Jersey 08543

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900025h

Reference28 articles.

1. Small Molecule Antagonists of the Corticotropin Releasing Factor (CRF)Receptor: Recent Medicinal Chemistry Developments

2. Corticotropin Releasing Factor (CRF) Receptor Modulators: Progress and Opportunities for New Therapeutic Agents

3. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

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