Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer-Reference-Cited by-同舟云学术

Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer

Published:2016-03-03 Issue:5 Volume:11 Page:1322-1331
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Bousquet Michelle S.¹,Ma Jia Jia¹,Ratnayake Ranjala,Havre Pamela A.,Yao Jin,Dang Nam H.,Paul Valerie J.²,Carney Thomas J.¹³,Dang Long H.,Luesch Hendrik¹

Affiliation:

1. Institute of Molecular and Cell Biology (IMCB), A*STAR, Proteos, Singapore 138673, Singapore

2. Smithsonian Marine Station, 701 Seaway Drive, Fort Pierce, Florida 34949, United States

3. Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, 636921, Singapore

Funder

National Cancer Institute

Singapore Eye Research Institute

Agency for Science, Technology and Research

University of Florida

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.5b00860

Reference50 articles.

1. A Comprehensive Survey of Ras Mutations in Cancer

2. Blocking Oncogenic Ras Signaling for Cancer Therapy

3. The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

4. Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/ AKT/mTOR Pathway in Cancer

5. Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes

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