A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels-Reference-Cited by-同舟云学术

A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels

Published:2020-09-03 Issue:9 Volume:15 Page:2539-2550
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Cooper Garry¹²³,Kang Soosung¹³⁴^ORCID,Perez-Rosello Tamara²,Guzman Jaime N.²,Galtieri Daniel²,Xie Zhong²,Kondapalli Jyothisri²,Mordell Jack²,Silverman Richard B.¹³⁵^ORCID,Surmeier D. James²

Affiliation:

1. Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, United States

2. Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States

3. Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States

4. College of Pharmacy, Ewha Womans University, Seoul 03760, Korea

5. Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States

Funder

National Institute of Neurological Disorders and Stroke

Michael J. Fox Foundation for Parkinson's Research

JPB Foundation

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.0c00577