Complementary Genomic, Bioinformatics, and Chemical Approaches Facilitate the Absolute Structure Assignment of Ionostatin, a Linear Polyketide from a Rare Marine-Derived Actinomycete-Reference-Cited by-同舟云学术

Complementary Genomic, Bioinformatics, and Chemical Approaches Facilitate the Absolute Structure Assignment of Ionostatin, a Linear Polyketide from a Rare Marine-Derived Actinomycete

Published:2020-08-27 Issue:9 Volume:15 Page:2507-2515
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Kim Min Cheol¹^ORCID,Winter Jaclyn M.²^ORCID,Cullum Reiko¹^ORCID,Li Zhifei¹^ORCID,Fenical William¹³⁴^ORCID

Affiliation:

1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, United States

2. Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States

3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States

4. Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, California 92093, United States

Funder

National Cancer Institute

Gordon and Betty Moore Foundation

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.0c00526

Reference34 articles.

1. Photopiperazines A–D, Photosensitive Interconverting Diketopiperazines with Significant and Selective Activity against U87 Glioblastoma Cells, from a Rare, Marine-Derived Actinomycete of the Family Streptomycetaceae

2. Structure of ionomycin - a novel diacidic polyether antibiotic having high affinity for calcium ions

3. Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites

4. Polyether ionophores

5. antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

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