Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature

Author:

Trapotsi Maria-Anna12,Mouchet Elizabeth3,Williams Guy3,Monteverde Tiziana3,Juhani Karolina3,Turkki Riku4,Miljković Filip5ORCID,Martinsson Anton5,Mervin Lewis6ORCID,Pryde Kenneth R.7,Müllers Erik8,Barrett Ian2,Engkvist Ola9ORCID,Bender Andreas1ORCID,Moreau Kevin10ORCID

Affiliation:

1. Department of Chemistry, Centre for Molecular Informatics, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

2. Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

3. High Throughput Screening, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Macclesfield SK10 4TF, U.K.

4. Data Sciences & Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-43183, Sweden

5. Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences R&D, AstraZeneca, Gothenburg SE-43183, Sweden

6. Molecular AI, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

7. Oncology Safety, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

8. Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-43183, Sweden

9. Molecular AI, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-43183, Sweden

10. Safety Innovation, Clinical Pharmacology and Safety Sciences R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

Funder

AstraZeneca

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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