<sup>19</sup>F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA–Guanine Transglycosylase-Reference-Cited by-同舟云学术

¹⁹F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA–Guanine Transglycosylase

Published:2022-06-28 Issue:7 Volume:17 Page:1745-1755
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Nguyen Andreas¹,Gemmecker Gerd²³,Softley Charlotte A.²³,Movsisyan Levon D.⁴,Pfaffeneder Toni⁴,Heine Andreas¹,Reuter Klaus¹,Diederich François⁴^ORCID,Sattler Michael²³^ORCID,Klebe Gerhard¹^ORCID

Affiliation:

1. Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 8, Marburg D-35032, Germany

2. Biomolecular NMR, Bavarian NMR Center, Technical University of Munich, Lichtenbergstraße 4, Garching D-85747, Germany

3. Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, Neuherberg 85764, Germany

4. Laboratory of Organic Chemistry, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, Zürich CH-8093, Switzerland

Funder

Deutsche Forschungsgemeinschaft

H2020 Marie Sklodowska-Curie Actions

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00080

Reference28 articles.

1. An Integrative Approach Combining Noncovalent Mass Spectrometry, Enzyme Kinetics and X-ray Crystallography to Decipher Tgt Protein-Protein and Protein-RNA Interaction

2. Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016

3. Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate

4. A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase11Edited by R. Huber

5. De Novo Design, Synthesis, and In Vitro Evaluation of Inhibitors for Prokaryotic tRNA-Guanine Transglycosylase: A Dramatic Sulfur Effect on Binding Affinity

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1. Ein Beispiel: Strukturbasiertes Design von Inhibitoren der tRNA-Guanin-Transglycosylase;Wirkstoffdesign;2023