Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain-Reference-Cited by-同舟云学术

Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain

Published:2019-02-14 Issue:4 Volume:14 Page:587-593
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

McNally Randall¹^ORCID,Li Qing¹,Li Kunhua¹,Dekker Carien²,Vangrevelinghe Eric³,Jones Matthew³,Chène Patrick³,Machauer Rainer⁴,Radimerski Thomas³,Eck Michael J.¹

Affiliation:

1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States

2. Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland

3. Oncology Research, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland

4. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland

Funder

National Institute of General Medical Sciences

Novartis Institutes for Biomedical Research

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.8b00722

Reference28 articles.

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4. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.

5. Jaks and cytokine receptors—An intimate relationship

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