Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC
Author:
Affiliation:
1. Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602, United States
2. Laboratory of Cellular Biophysics, The Rockefeller University, New York, New York 10065, United States
Funder
National Cancer Institute
U.S. Department of Defense
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acschembio.4c00237
Reference58 articles.
1. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
2. PROTAC Technology: Opportunities and Challenges
3. The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination
4. Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs
5. A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer
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