Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains

Author:

Sekirnik Angelina R.1,Reynolds Jessica K.1,See Larissa1,Bluck Joseph P.12,Scorah Amy R.1,Tallant Cynthia3,Lee Bernadette1,Leszczynska Katarzyna B.4,Grimley Rachel L.5,Storer R. Ian5,Malattia Marta6,Crespillo Sara6,Caria Sofia6,Duclos Stephanie6,Hammond Ester M.4ORCID,Knapp Stefan78ORCID,Morris Garrett M.9,Duarte Fernanda1ORCID,Biggin Philip C.2ORCID,Conway Stuart J.1ORCID

Affiliation:

1. Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.

2. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

3. Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 3TA, U.K.

4. Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, U.K.

5. Worldwide Medicinal Chemistry, Discovery Biology, Pfizer Ltd, The Portway, Granta Park, Cambridge CB21 6GS, U.K.

6. Evotec (UK) Ltd, 90 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.

7. Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany

8. Structural Genomics Consortium, Buchmann Institute for Life Sciences (BMLS), Goethe University, Max-von-Laue-Strasse 15, D-60438 Frankfurt am Main, Germany

9. Department of Statistics, University of Oxford, 24-29 St Giles’, Oxford OX1 3LB, U.K.

Funder

Engineering and Physical Sciences Research Council

Vertex Pharmaceuticals

Agency for Science, Technology and Research

Pfizer

Lady Margaret Hall, University of Oxford

GlaxoSmithKline

Merck

Syngenta International

St Hugh?s College, Oxford

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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