Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

Author:

Leandro João12ORCID,Khamrui Susmita3,Wang Hui34,Suebsuwong Chalada34,Nemeria Natalia S.5,Huynh Khoi34,Moustakim Moses34,Secor Cody3,Wang May12,Dodatko Tetyana12,Stauffer Brandon6,Wilson Christopher G.7,Yu Chunli16,Arkin Michelle R.7ORCID,Jordan Frank5,Sanchez Roberto34,DeVita Robert J.34ORCID,Lazarus Michael B.3ORCID,Houten Sander M.12ORCID

Affiliation:

1. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

2. Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

3. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

4. Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

5. Department of Chemistry, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, United States

6. Mount Sinai Genomics, Inc, Stamford, Connecticut 06902, United States

7. Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States

Funder

U.S. Department of Health and Human Services

U.S. Department of Energy

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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