Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity

Author:

Billon Cyrielle1,Sitaula Sadichha1,Banerjee Subhashis2,Welch Ryan3,Elgendy Bahaa1ORCID,Hegazy Lamees1ORCID,Oh Tae Gyu3,Kazantzis Melissa4,Chatterjee Arindam2,Chrivia John2,Hayes Matthew E.5,Xu Weiyi6,Hamilton Angelica7,Huss Janice M.7,Zhang Lilei6ORCID,Walker John K.28,Downes Michael3,Evans Ronald M.39,Burris Thomas P.15ORCID

Affiliation:

1. Center for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, Missouri 63110, United States

2. Department of Pharmacology & Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States

3. Gene Expression Laboratory Salk Institute for Biological Studies, La Jolla, California 92037, United States

4. The Scripps Research Institute Jupiter, Jupiter, Florida 33458, United States

5. University of Florida Genetics Institute, Gainesville, Florida 32610, United States

6. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, United States

7. Department of Molecular & Cellular Endocrinology, City of Hope, Duarte, California 91010, United States

8. Department of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States

9. Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, United States

Funder

Howard Hughes Medical Institute

American Diabetes Association

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

Stand Up To Cancer

National Institute on Aging

Leona M. and Harry B. Helmsley Charitable Trust

National Institute of Mental Health

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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