CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16-Reference-Cited by-同舟云学术

CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16

Published:2023-01-19 Issue:2 Volume:18 Page:331-339
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Shergalis Andrea G.¹^ORCID,Marin Violeta L.¹,Rhee David Y.¹^ORCID,Senaweera Sameera¹,McCloud Rebecca L.¹,Ronau Judith A.¹,Hutchins Charles W.¹,McLoughlin Shaun¹,Woller Kevin R.¹,Warder Scott E.¹,Vasudevan Anil¹^ORCID,Reitsma Justin M.¹

Affiliation:

1. Drug Discovery Science & Technology, AbbVie Inc, North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00747

Reference44 articles.

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4. Harnessing the Power of Proteolysis for Targeted Protein Inactivation

5. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

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