Structure-Guided Design of a Potent and Specific Inhibitor against the Genomic Mutator APOBEC3A-Reference-Cited by-同舟云学术

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Structure-Guided Design of a Potent and Specific Inhibitor against the Genomic Mutator APOBEC3A

Published:2022-12-08 Issue:12 Volume:17 Page:3379-3388
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Serrano Juan C.¹,von Trentini Dora²,Berríos Kiara N.¹,Barka Aleksia³,Dmochowski Ivan J.²^ORCID,Kohli Rahul M.³^ORCID

Affiliation:

1. Graduate Group in Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

2. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

3. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

Funder

National Cancer Institute

National Institute of General Medical Sciences

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00796

Reference56 articles.

1. APOBECs and virus restriction

2. Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination

3. APOBEC Enzymes as Targets for Virus and Cancer Therapy

4. Human APOBEC3G-Mediated Editing Can Promote HIV-1 Sequence Diversification and Accelerate Adaptation to Selective Pressure

5. Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2

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1. Regulation, functional impact, and therapeutic targeting of APOBEC3A in cancer;DNA Repair;2024-09

2. APOBEC3C‐mediated NF‐κB activation enhances clear cell renal cell carcinoma progression;Molecular Oncology;2024-08-26

3. An overview of the functions and mechanisms of APOBEC3A in tumorigenesis;Acta Pharmaceutica Sinica B;2024-08

4. The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis;PLOS Biology;2024-07-08

5. Synthesis of 1,4-azaphosphinine nucleosides and evaluation as inhibitors of human cytidine deaminase and APOBEC3A;Beilstein Journal of Organic Chemistry;2024-05-15

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