Switching Prenyl Donor Specificities in Squalene Synthase-Like Aromatic Prenyltransferases from Bacterial Carbazole Alkaloid Biosynthesis

Author:

Shen Yaoyao1,Zhang Liu1,Yang Ming1,Shi Ting2ORCID,Li Yongzhen2,Li Lei1,Yu Yi3ORCID,Deng Hai4ORCID,Lin Hou-Wen1ORCID,Zhou Yongjun1ORCID

Affiliation:

1. Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

2. State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

3. Institute of TCM and Natural Products, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China

4. Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, U.K.

Funder

Royal Society

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Innovative Research Team of High-level Local Universities in Shanghai

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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