Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production-Reference-Cited by-同舟云学术

Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production

Published:2021-04-01 Issue:4 Volume:16 Page:740-752
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Taylor Isabelle R.¹^ORCID,Paczkowski Jon E.²³,Jeffrey Philip D.¹,Henke Brad R.⁴,Smith Chari D.¹,Bassler Bonnie L.¹⁵^ORCID

Affiliation:

1. Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States

2. Department of Health, Wadsworth Center, Albany, New York 12208, United States

3. Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York 12201, United States

4. Opti-Mol Consulting, LLC, Cary, North Carolina 27518, United States

5. Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States

Funder

Howard Hughes Medical Institute

Division of Molecular and Cellular Biosciences

National Institute of General Medical Sciences

New York Community Trust Foundation

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.1c00049

Reference45 articles.

1. The Epidemiology, Pathogenesis and Treatment of Pseudomonas aeruginosa Infections

2. Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients

3. P. aeruginosa Burn Infections: Pathogenesis and Treatment

4. Pseudomonas aeruginosaBiofilms: Host Response and Clinical Implications in Lung Infections

5. Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The relationship between pqs gene expression and acylhomoserine lactone signaling in Pseudomonas aeruginosa;Journal of Bacteriology;2024-09-05

2. A Systematic Hierarchical Virtual Screening Model for RhlR Inhibitors Based on PCA, Pharmacophore, Docking, and Molecular Dynamics;International Journal of Molecular Sciences;2024-07-22

3. Miconazole and phenothiazine hinder the quorum sensing regulated virulence in Pseudomonas aeruginosa;The Journal of Antibiotics;2024-05-09

4. The Relationship ofpqsGene Expression to Acylhomoserine Lactone Signaling inPseudomonas aeruginosa;2024-03-22

5. The end of the reign of a “master regulator’’? A defect in function of the LasR quorum sensing regulator is a common feature of Pseudomonas aeruginosa isolates;mBio;2024-03-13