Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux-Reference-Cited by-同舟云学术

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Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux

Published:2019-05-15 Issue:6 Volume:14 Page:1110-1114
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Komulainen Emilia¹,Pennicott Lewis²,Le Grand Darren²,Caldecott Keith W.¹³^ORCID

Affiliation:

1. Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom

2. Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, United Kingdom

3. Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, 4, Czech Republic

Funder

Wellcome Trust

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.9b00144

Reference15 articles.

1. A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

2. TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

3. TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

4. DNA topoisomerase-targeting chemotherapeutics: what’s new?

5. Targeting DNA topoisomerase II in cancer chemotherapy

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1. Cancer sensitizing effect of deazaflavin analogs is associated with increased intracellular drug accumulation;European Journal of Pharmaceutical Sciences;2024-02

2. Synthesis of Myrtucommulone D: A Selective Inhibitor of Tyrosyl-DNA Phosphodiesterase 2 Promoting Drug Resistance Reversal in Lung Cancer Cells;Revista Brasileira de Farmacognosia;2024-01-05

3. Synthesis of the New Derivatives of Usnic Acid and Study of Their Inhibiting Activity against Tyrosyl-DNA-Phosphodiesterases 1 and 2;CHEM SUSTAIN DEV;2023

4. Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities;European Journal of Medicinal Chemistry;2022-08

5. The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors;Bioorganic Chemistry;2021-06

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