Aggregated Compound Biological Signatures Facilitate Phenotypic Drug Discovery and Target Elucidation-Reference-Cited by-同舟云学术

Aggregated Compound Biological Signatures Facilitate Phenotypic Drug Discovery and Target Elucidation

Published:2016-09-14 Issue:11 Volume:11 Page:3024-3034
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Cortes Cabrera Alvaro¹,Lucena-Agell Daniel²,Redondo-Horcajo Mariano²,Barasoain Isabel²,Díaz José Fernando²,Fasching Bernhard³,Petrone Paula M.¹

Affiliation:

1. Pharma Research & Early Development Informatics (pREDi), Roche Innovation Center Basel, Basel, Switzerland

2. Laboratory of Microtubule Stabilizing Agents, Department of Physical and Chemical Biology, Centro de Investigaciones Biológicas, CIB, CSIC, Madrid, Spain

3. Medicinal Chemistry, Pharma Research & Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland

Funder

F. Hoffmann-La Roche

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.6b00358

Reference54 articles.

1. Network pharmacology

2. Shifting from the single to the multitarget paradigm in drug discovery

3. Network pharmacology: the next paradigm in drug discovery

4. Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines

5. Target identification and mechanism of action in chemical biology and drug discovery

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