Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth

Author:

Bozzola Tiago12,Scalise Mariafrancesca3,Larsson Christer U.4,Newton-Vesty Michael C.5,Rovegno Caterina1,Mitra Ankita1,Cramer Jonathan26ORCID,Wahlgren Weixiao Yuan7,Radhakrishnan Santhakumari Partha89,Johnsson Richard E.10,Schwardt Oliver2,Ernst Beat2ORCID,Friemann Rosmarie1112,Dobson Renwick C. J.513,Indiveri Cesare314ORCID,Schelin Jenny4,Nilsson Ulf J.1ORCID,Ellervik Ulf1ORCID

Affiliation:

1. Centre for Analysis and Synthesis, Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden

2. Molecular Pharmacy Group, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland

3. Department DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P. Bucci 4C, 87036 Arcavacata di Rende, Italy

4. Division of Applied Microbiology, Department of Chemistry, Lund University, 22100 Lund, Sweden

5. Biomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, 8140 Christchurch, New Zealand

6. Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University of Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany

7. Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530 Gothenburg, Sweden

8. Institute for Stem Cell Science and Regenerative Medicine, Bengaluru, Karnataka 560065, India

9. Manipal Academy of Higher Education, Tiger Circle Road, Manipal, Karnataka 576104, India

10. Red Glead Discovery AB, Medicon Village, 223 81 Lund, Sweden

11. Department of Clinical Microbiology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden

12. Centre for Antibiotic Resistance Research (CARe), University of Gothenburg, 40530 Gothenburg, Sweden

13. Bio21 Molecular Science and Biotechnology Institute, Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, Victoria 3010, Australia

14. Institute of Biomembranes, Bioenergetics and Molecular Biotechnology (IBIOM), National Research Council−CNR, Via Amendola 122/O, 70126 Bari, Italy

Funder

Svenska Forskningsrådet Formas

Ministry of Business, Innovation and Employment

Department of Biotechnology, Ministry of Science and Technology, India

VINNOVA

H2020 Marie Sklodowska-Curie Actions

Lunds Universitet

Royal Society Te Aparangi

Ministero dell'Università e della Ricerca

Centre for Antibiotic Resistance Research, University of Gothenburg

Biomolecular Interaction Centre

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Reference54 articles.

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