Exploration of Hygromycin B Biosynthesis Utilizing CRISPR-Cas9-Associated Base Editing
Author:
Affiliation:
1. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People’s Republic of China
Funder
Ministry of Science and Technology of the People's Republic of China
State Key Laboratory of Microbial Metabolism
National Natural Science Foundation of China
Publisher
American Chemical Society (ACS)
Subject
Molecular Medicine,General Medicine,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acschembio.0c00071
Reference28 articles.
1. The Isolation of a Second Antibiotic from Streptomyces hygroscopicus
2. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
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4. Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B
5. Hygromycin B Inhibition of Protein Synthesis and Ribosome Biogenesis in Escherichia coli
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