Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD-Reference-Cited by-同舟云学术

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD

Published:2020-11-16 Issue:12 Volume:15 Page:3112-3123
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Ursu Andrei¹,Wang Kye Won²,Bush Jessica A.¹,Choudhary Shruti¹,Chen Jonathan L.¹^ORCID,Baisden Jared T.¹,Zhang Yong-Jie³,Gendron Tania F.³,Petrucelli Leonard³,Yildirim Ilyas²^ORCID,Disney Matthew D.¹^ORCID

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States

2. Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, Florida 33458, United States

3. Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, Florida 32224, United States

Funder

National Institute of Neurological Disorders and Stroke

Target ALS

Deutsche Forschungsgemeinschaft

Amyotrophic Lateral Sclerosis Association

Nelson Family Fund

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.0c00049

Reference61 articles.

1. C9orf72-mediated ALS and FTD: multiple pathways to disease

2. ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

3. Amyotrophic lateral sclerosis

4. The phenotypic variability of amyotrophic lateral sclerosis

5. Decoding ALS: from genes to mechanism

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