Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis

Author:

Tolentino Collado Jinnette1,Iuliano James N.1ORCID,Pirisi Katalin2,Jewlikar Samruddhi1,Adamczyk Katrin3,Greetham Gregory M.4,Towrie Michael4,Tame Jeremy R. H.5ORCID,Meech Stephen R.3ORCID,Tonge Peter J.1ORCID,Lukacs Andras2ORCID

Affiliation:

1. Department of Chemistry, Stony Brook University, New York, New York 11794, United States

2. Department of Biophysics, Medical School, University of Pecs, Szigeti Street 12, Pecs 7624, Hungary

3. School of Chemistry, University of East Anglia, Norwich NR4 7TJ, U.K.

4. Central Laser Facility, Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0QX, U.K.

5. Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama 230-0045, Japan

Funder

Engineering and Physical Sciences Research Council

Division of Molecular and Cellular Biosciences

National Institute of General Medical Sciences

Hungarian National Research and Innovation Office

?ltal?nos Orvostudom?nyi Kar

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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