A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells-Reference-Cited by-同舟云学术

A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells

Published:2022-08-31 Issue:9 Volume:17 Page:2595-2604
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Moore Keith P.¹,Schwaid Adam G.¹^ORCID,Tudor Matthew²^ORCID,Park Sangho³,Beshore Douglas C.⁴^ORCID,Converso Antonella⁴,Shipe William D.⁴,Anand Rajan¹,Lan Ping¹^ORCID,Moningka Remond¹,Rothman Deborah M.¹^ORCID,Sun Wanying¹,Chi An¹,Cornella-Taracido Ivan¹,Adam Gregory C.³,Bahnck-Teets Carolyn³,Carroll Steven S.³,Fay John F.³,Goh Shih Lin³,Lusen Jeffrey³,Quan Shuo³,Rodriguez Silveria³,Xu Min³,Andrews Christine L.³,Song Cheng³,Filzen Tracey⁵,Li Jing⁵,Hollenstein Kaspar²,Klein Daniel J.²,Lammens Alfred⁶,Lim U-Ming⁷,Fang Zhiyu⁸,McHale Carolyn⁸,Li Yuan⁸,Lu Meiqing⁸,Diamond Tracy L.⁸,Howell Bonnie J.⁸,Zuck Paul⁸,Balibar Carl J.⁸

Affiliation:

1. Chemical Biology, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

3. Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States

4. Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

5. Screening and Protein Sciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States

6. Proteros Biostructures GmbH, Bunsenstr, Martinsried 82152, Germany

7. Genome and Biomarker Sciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States

8. Infectious Disease and Vaccines, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Funder

Merck

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00515

Reference21 articles.

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2. Eliminating HIV reservoirs for a cure: the issue is in the tissue

3. HIV “shock and kill” therapy: In need of revision

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5. NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal

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