SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies

Author:

Valdes-Balbin Yury1,Santana-Mederos Darielys1,Quintero Lauren1,Fernández Sonsire1,Rodriguez Laura1,Sanchez Ramirez Belinda2,Perez-Nicado Rocmira1,Acosta Claudia1,Méndez Yanira3ORCID,Ricardo Manuel G.3,Hernandez Tays2,Bergado Gretchen2,Pi Franciscary2,Valdes Annet2,Carmenate Tania2,Ramirez Ubel1,Oliva Reinaldo1,Soubal Jean-Pierre1,Garrido Raine1,Cardoso Felix1,Landys Mario1,Gonzalez Humberto1,Farinas Mildrey1,Enriquez Juliet4,Noa Enrique4,Suarez Anamary4,Fang Cheng5,Espinosa Luis A.6,Ramos Yassel6ORCID,González Luis Javier6ORCID,Climent Yanet1,Rojas Gertrudis2,Relova-Hernández Ernesto2,Cabrera Infante Yanelys2,Losada Sum Lai2,Boggiano Tammy2,Ojito Eduardo2,León Kalet2,Chiodo Fabrizio178ORCID,Paquet Françoise9ORCID,Chen Guang-Wu10,Rivera Daniel G.3ORCID,Garcia-Rivera Dagmar1,Verez Bencomo Vicente1ORCID

Affiliation:

1. Finlay Vaccine Institute, 200 and 21 Street, Havana 11600, Cuba

2. Center of Molecular Immunology, P.O. Box 16040, 216 St., Havana, Cuba

3. Laboratory of Synthetic and Biomolecular Chemistry, Faculty of Chemistry, University of Havana, Zapata y G, Havana 10400, Cuba

4. National Civil Defense Research Laboratory, Mayabeque 32700, Cuba

5. Shanghai Fenglin Glycodrug Promotion Center, Shanghai 200032, China

6. Center for Genetic Engineering and Biotechnology, Ave 31 e/158 y 190, Havana 10600, Cuba

7. Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands

8. Institute of Biomolecular Chemistry, National Research Council (CNR), Pozzuoli 80078, Napoli, Italy

9. Centre de Biophysique Moléculaire, CNRS UPR 4301, rue Charles Sadron F-45071, Orléans, Cedex 2, France

10. Chengdu Olisynn Biotech. Co. Ltd., and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China

Funder

Fondo de Ciencia e Innovacion

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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