Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity-Reference-Cited by-同舟云学术

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

Published:2018-01-04 Issue:3 Volume:13 Page:636-646
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Kundel Franziska¹^ORCID,De Suman¹,Flagmeier Patrick¹^ORCID,Horrocks Mathew H.¹,Kjaergaard Magnus¹,Shammas Sarah L.¹,Jackson Sophie E.¹,Dobson Christopher M.¹,Klenerman David¹

Affiliation:

1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom

Funder

Det Frie Forskningsråd

Studienstiftung des Deutschen Volkes

Christ's College, University of Cambridge

H2020 Marie Sklodowska-Curie Actions

Boehringer Ingelheim Stiftung

Frances and Augustus Newman Foundation

H2020 European Research Council

Lundbeckfonden

Herchel Smith Foundation

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acschembio.7b01039

Reference56 articles.

1. The ordered assembly of tau is the gain‐of‐toxic function that causes human tauopathies

2. Observations on the brains of demented old people

3. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

4. Protein Misfolding, Functional Amyloid, and Human Disease

5. Heat-shocked Neuronal PC12 Cells Reveal Alzheimer's Disease-associated Alterations in Amyloid Precursor Protein and Tau

Cited by 91 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Selenoprotein W modulates tau homeostasis in an Alzheimer’s disease mouse model;Communications Biology;2024-07-17

2. Identification of novel small molecule chaperone activators for neurodegenerative disease treatment;2024-07-17

3. Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions into amyloid fibrils;2024-06-16

4. Experimental and computational investigation of the effect of Hsc70 structural variants on inhibiting amylin aggregation;Biophysical Chemistry;2024-06

5. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons;Acta Neuropathologica;2024-03-12