Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes

Author:

van der Gracht Anouk M. F.1,de Geus Mark A. R.1,Camps Marcel G. M.2,Ruckwardt Tracy J.3,Sarris Alexi J. C.1,Bremmers Jessica1,Maurits Elmer1,Pawlak Joanna B.1,Posthoorn Michelle M.1,Bonger Kimberly M.4ORCID,Filippov Dmitri V.1,Overkleeft Herman S.1ORCID,Robillard Marc S.5ORCID,Ossendorp Ferry2,van Kasteren Sander I.1ORCID

Affiliation:

1. Leiden Institute of Chemistry and The Institute for Chemical Immunology, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

2. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

3. Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institute of Health, 40 Convent Drive, Building 40, Bethesda, Maryland 20814, United States

4. Department of Biomolecular Chemistry, Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands

5. Tagworks Pharmaceuticals, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands

Funder

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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