Discovery and Biosynthesis of the Cytotoxic Polyene Terpenomycin in Human Pathogenic Nocardia

Author:

Herisse Marion1,Ishida Keishi2,Staiger-Creed Jordan1,Judd Louise1,Williams Spencer J.34ORCID,Howden Benjamin P.15,Stinear Timothy P.1ORCID,Dahse Hans-Martin6,Voigt Kerstin78,Hertweck Christian29ORCID,Pidot Sacha J.1ORCID

Affiliation:

1. Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia

2. Department of Biomolecular Chemistry, Leibniz Institute, for Natural Product Chemistry and Infection Biology (HKI), Beutenbergstrasse 11a, Jena 07745, Germany

3. School of Chemistry, University of Melbourne, Melbourne, Victoria 3000, Australia

4. Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria 3000, Australia

5. Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria3000, Australia

6. Department of Infection Biology, Leibniz Institute, for Natural Product Chemistry and Infection Biology (HKI), Beutenbergstrasse 11a, Jena 07745, Germany

7. Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstrasse 11a, Jena 07745, Germany

8. Institute of Microbiology, Friedrich Schiller University Jena, 07743 Jena, Germany

9. Natural Product Chemistry, Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena 07743, Germany

Funder

National Health and Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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