Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms-Reference-Cited by-同舟云学术

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Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms

Published:2019-05-13 Issue:6 Volume:14 Page:1337-1351
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Ketkar Amit¹,Maddukuri Leena¹,Penthala Narsimha R.²,Reed Megan R.¹,Zafar Maroof K.¹,Crooks Peter A.²,Eoff Robert L.¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States

2. Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States

Funder

UAMS College of Medicine

Arkansas Breast Cancer Program

Little Rock Envoys Seeds of Science Award

Barton Endowment

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.9b00304

Reference63 articles.

1. Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities

2. Translesion DNA polymerases in eukaryotes: what makes them tick?

3. Nonlinear partial differential equations and applications: Pol protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene

4. Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa

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1. Temozolomide resistance mechanisms: unveiling the role of translesion DNA polymerase kappa in glioblastoma spheroids in vitro;Bioscience Reports;2024-05

2. Catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis;2023-11-06

3. Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer;European Journal of Medicinal Chemistry;2023-02

4. Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy;NAR Cancer;2023-01-11

5. Leveraging the replication stress response to optimize cancer therapy;Nature Reviews Cancer;2022-11-02

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