Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module-Reference-Cited by-同舟云学术

Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module

Published:2018-04-27 Issue:6 Volume:13 Page:1640-1650
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Skiba Meredith A.¹²,Sikkema Andrew P.¹²,Moss Nathan A.³,Lowell Andrew N.¹,Su Min¹,Sturgis Rebecca M.¹,Gerwick Lena³^ORCID,Gerwick William H.³⁴^ORCID,Sherman David H.¹⁵⁶⁷^ORCID,Smith Janet L.¹²^ORCID

Affiliation:

1. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States

2. Department of Biological Chemistry, University of Michigan, Ann Arbor Michigan 48109, United States

3. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, United States

4. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States

5. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

6. Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

7. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.8b00252

Reference49 articles.

1. Marine natural products

2. Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

3. Total Structure Determination of Apratoxin A, a Potent Novel Cytotoxin from the Marine Cyanobacterium Lyngbya majuscula

4. Milnamide A, an unusual cytotoxic tripeptide from the marine sponge Auletta cf. constricta

5. The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cβ-Methylation during Polytheonamide Biosynthesis

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