Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains
Author:
Affiliation:
1. Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto 606-8501, Japan
Funder
Ministry of Education, Culture, Sports, Science, and Technology
Japan Society for the Promotion of Science
Publisher
American Chemical Society (ACS)
Subject
Molecular Medicine,General Medicine,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acschembio.5b00595
Reference54 articles.
1. Polyketide and Nonribosomal Peptide Antibiotics: Modularity and Versatility
2. Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics
3. Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase
4. Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology
5. Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity
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