Application of an Integrated GPCR SAR-Modeling Platform To Explain the Activation Selectivity of Human 5-HT2C over 5-HT2B
Author:
Affiliation:
1. Evotec (U.K.) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire, OX14 4RZ, United Kingdom
2. Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
Funder
Engineering and Physical Sciences Research Council
Royal Society
Biotechnology and Biological Sciences Research Council
Evotec AG
Publisher
American Chemical Society (ACS)
Subject
Molecular Medicine,General Medicine,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acschembio.5b01045
Reference45 articles.
1. Structure and function of serotonin G protein-coupled receptors
2. Drugs and Valvular Heart Disease
3. GPCR structures in drug design, emerging opportunities with new structures
4. GPCR crystal structures: Medicinal chemistry in the pocket
5. From G Protein-coupled Receptor Structure Resolution to Rational Drug Design
Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Pharmaceutical Industry—Academia Cooperation;Recent Advances of the Fragment Molecular Orbital Method;2021
2. Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development;Current Topics in Medicinal Chemistry;2019-09-16
3. Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT2C Agonists;Molecules;2019-09-05
4. The Serotonergic System;Chemical Biology of Neurodegeneration;2019-08-09
5. Characterising GPCR–ligand interactions using a fragment molecular orbital-based approach;Current Opinion in Structural Biology;2019-04
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3